The FEI SciosĀ  combines a high resolution field emission scanning electron microscope (SEM) with the ability to mill and image a sample using a focused ion beam (FIB). By concurrent milling of the sample using the FIB and imaging using the SEM it is possible to selectively image sub-surface features, prepare site-specific TEM samples and fabricate nano-structures.
The FIB is capable of rapidly milling away the sample using high beam currents or using lower beam currents to image the sample and mill fine features.The Scios is equipped with a gas injection system allows carbon or platinum to be deposited on the sample to protect surface features during TEM sample preparation or fabricate electrical current pathways. Serial milling with the FIB and imaging with the SEM can be used to produce three-dimensional reconstructions.